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A urine albumin creatinine ratio (UACR) is recommended in detection of albuminuria and consistent with the gold standard 24 hour urine collection

These lactylation modifications modulate metabolic processes by influencing enzyme activity, indicating a feedback mechanism constituted by lactate-lactylation-metabolic reprogramming

Indeed, the CuAAC can be performed site-selectively with complete conversion 34 and has been used in many significant applications, such as the generation of PEGylated proteins 87 , the generation of dual PTM glycoprotein mimics due to its orthogonality to existing cysteine chemistry 34,35 , cellular proteomic analysis (BONCAT) 80 , a quantitative method for primary cell proteomics (QuaNCAT) 88 , and the construction of highly-valent protein nanoparticles 89

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