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Case presentation The patient is a 76-year-old female who was admitted to the US hospital with severe pancytopenia found at her primary care physician's (PCP) office

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Oncotarget 7 , 2027120281 (2016)

Although efficacy for anti-TNF agents has been proven, up to 30% of patients have no clinical improvement after initiation of anti-TNF therapy (primary nonresponse), and up to 50% of patients lose response over time (secondary nonresponse) [173]