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As mentioned in the section above, IDH1 catalyzes typically the conversion of isocitrate to -KG, but the mutant isoform converts -KG into D-2HG instead, which has been shown to inhibit cellular differentiation through epigenetic alterations [19]

It has been described in publications that an analogue of this domain, AOD9604, can increase lipolytic sensitivity and affect the expression of receptors beta-3 adrenergic in adipose tissue, and increase fat oxidation and energy expenditure in animal models

HOW SUPPLIED HOW SUPPLIED SECTION Cyanocobalamin Injection, USP 1000 mcg/mL NDC 69680-112-10 1 mL Vial Boxes of 10 NDC 69680-112-25 1 mL Vial Boxes of 25 NDC 69680-113-99 10 mL Multiple Dose Vial Boxes of 10 NDC 69680-121-30 30 mL Multiple Dose Vial Boxes of 1 NDC 69680-121-05 30 mL Multiple Dose Vial Boxes of 5 NDC 69680-121-10 30 mL Multiple Dose Vial Boxes of 10 SPL UNCLASSIFIED SECTION SPL UNCLASSIFIED SECTION Product of France Manufactured for: Vitruvias Therapeutics Auburn, Alabama 36830 Code No.: I112 0923R5 Revised: 02/2024 To request additional information or if you have questions concerning this drug please phone Vitruvias Therapeutics at 1-844-451-5944