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In melanoma and breast cancer mouse models, it has been observed that mice fed a low-protein diet (4% kcal protein) exhibit reduced IGF-1 levels and slower tumor progression compared to those fed a high-protein diet (18% kcal protein)

succinate, -ketoglutarate, citrate and itaconate) that impacts the activation of LPS-stimulated macrophages (Reference Harber, de Goede and Verberk23,Reference Tannahill, Curtis and Adamik24)

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Individuals with pre-existing health issues such as liver disease, kidney problems, or those undergoing chemotherapy should be especially cautious