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[] However, the role of FIS1 in direct DRP1-mediated mitochondrial fission in mammals is unclear because FIS1 deficiency is associated with mild or no mitochondrial fission defects

The problem with that is, of course, you can't infer cause from that, but the negative to me is suggestive that at the very least, carbohydrate content matters when it comes to IGF-1 signaling