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HLC transplantation remains entirely preclinical, and factors that limit HLC engraftment in liver disease mouse models include poor survival, proliferation, and maturation of transplanted cells

While the wild-type strain deploys methanol chemoreceptor- and flagellin protein-dependent methanol chemotaxis, methylotaxis, to actively reach stomatal cavities, even a non-motile mutant lacking flagella could colonize the phyllosphere (Katayama et al., 2025)

While oral tablets and sublingual troches exist, subcutaneous injection remains the most effective delivery method

[DOI] [PMC free article] [PubMed] [Google Scholar] 7.Bernal W., Lee W.M., Wendon J., Larsen F.S., Williams R