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The significant appetite suppression caused by tirzepatide often leads to reduced caloric intake, which is therapeutic for weight loss but may result in insufficient energy consumption for some patients

However, for B12, if any part of that complex digestive process is compromised especially the intrinsic factor or the absorption sites in the intestine then a significant portion of the B12 from a tablet might never reach your bloodstream

These include: pernicious anaemia where your immune system attacks healthy cells in your stomach, preventing your body absorbing vitamin B12 from the food you eat

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