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J Chem Theory Comput 11:436450

B6 (Pyridoxine HCL) is part of more than 100 enzymes that engage in amino acid, lipid and carbohydrate metabolism, including hormones and neurotransmitters

Buffered NAD+ ships with a pH stabilizer (most commonly Tris) that brings the reconstituted solution closer to physiological pH (~7-8.5), while unbuffered NAD+ reconstitutes acidic (~pH 3-4) and is more often associated with injection-site stinging