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ScGrx7 is particularly suited for unbiased kinetic and mechanistic studies because of its high activity, the absence of ironsulfur clusters in enzyme preparations and the lack of additional cysteine residues 11 (glutaredoxins with two or more cysteine residues have complex kinetics because of alternative redox states and reactions 10,12,14,17,30,31,32,33 )

Marins 3 , Kaili Ren 3 , Marco Vilela 3 , Thikshaya Mahendran 4 , Amanda Sees 2 , May Hagiwara 3 and Rohit Loomba 5 , (1)University of Florida, Gainesville, FL, USA, (2)Iqvia, Plymouth Meeting, PA, USA, (3)Takeda Development Center Americas, Inc., Cambridge, MA, USA, (4)Iqvia, Bengaluru, India, (5)University of California, San Diego, San Diego, CA Background: Diagnosis (dx) of alpha-1 antitrypsin deficiency (AATD)-associated liver disease (LD) is challenging due to the variable risk and asymptomatic nature of the disease

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Adults that declined (vs enrolled) were temporally closer to time of LT (21.9 mo vs 38.9 mo, p =0.049), more frequently had comorbid psychiatric diagnosis (36.4 vs 7.1%, p =0.006), and history post-LT of slip or relapse (39.1 vs 14.6%, p =0.01)