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The use of d4T stands the highest risk among NRTIs for TG and LDL elevation

Effect of aluminium on nitrogen assimilation in roots of Lotus japonicus

Endogenous purines originate from nucleic acid breakdown of damaged/apoptotic cells, along with adenine and guanine degradation, whereas exogenous purines are primarily derived from dietary sources, including fructose-rich beverages and purine-rich foods (e.g., meat and seafood) (Weaver, 2019)