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Open medicine: a peer-reviewed, independent, open-access journal

Li S, Li W, Wu X, Zhang B, Liu L, Yin L

reported that inhibition of the Xc- transport system using sulfasalazine, while ineffective as a monotherapy, was highly effective to eliminate AML cell lines when combined with Buthionine sulfoximine (BSO), an inhibitor of glutamyl cysteine synthetase, the first enzyme in the synthesis of GSH