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While historically listed with an "unknown status," recent data releases in late 2025 and early 2026 have clarified the safety profile that helped justify the Category 1 reclassification. Study Design: A randomized, placebo-controlled, double-blind Phase 1 pilot study

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The Advisory Committee on Immunization Practices (ACIP) recommends Zostavax only for adults 60 years old, even though it was approved by the FDA for use in those 50 years old.10 SHINGRIX The new recombinant vaccine contains a surface VZV glycoprotein E (gE) antigen obtained from cultured, genetically engineered Chinese hamster ovary cells that triggers a targeted immune response to VZV