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Although Trxs recognize multiple non-homologous substrates, solved protein structures of disulfide-linked Trx-substrate reaction intermediate mimics have provided evidence for recognition of structural motifs in target proteins by Trxs (Qin et al., 1995, 1996

189 Until now there has been limited knowledge about the antioxidant status in AATD individuals, so the usefulness of antioxidant therapies remains to be investigated