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This work was mostly done in Japan in the 1950s and 1960s, because beriberi was a widespread health problem in Japan [58]

Mitochondrial ROS and its oxidation products are known to play a prominent role in inflammasome activation, whereas the role of NOX is highly dispensable ( 3.3 Metabolic reprogramming in M2 macrophages Unlike M1 macrophages, M2 macrophages hold an intact TCA cycle and enhanced mitochondrial OXPHOS