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High-sensitivity variants suggest you may experience more pronounced initial side effects, including dizziness, allowing your prescriber to use a slower titration schedule or lower starting dose to minimize symptoms

Starting with a higher concentration gives you a larger window before the dissolved hydrogen drops below meaningful levels

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Cobalamin and holo-TC levels in the placenta, cord blood, and newborn serum correlate with maternal levels, but are 23 fold higher (Luhby et al., 2006), providing the newborn with a liver store of about 25 g cobalamin assumed to be sufficient for the first year of life (McPhee et al., 1988)