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As the second most prevalent neurodegenerative disease globally, it manifests with motor symptoms such as resting tremor, bradykinesia, rigidity, and postural instability ( Current clinical treatments for PD are based on its pathophysiology, with therapies including dopamine receptor agonists (e.g., levodopa, pramipexole), anticholinergic drugs (e.g., benztropine), and monoamine oxidase inhibitors (MAOIs) (e.g., rasagiline) ( The pursuit of innovative drug development and more effective approaches for preventing and treating PD has remained a central focus in pharmaceutical research

Hydrogen peroxide-mediated toxicity is normally kept in check by several antioxidant enzymes that are essential in preserving cellular homeostasis

Folic acid, vitamin K, and fiber further support neurotransmitter synthesis and gutbrain interactions (180182)

An involvement of SR-B1 mediated PI3K-Akt-eNOS signaling in HDL-induced cyclooxygenase 2 expression and prostacyclin production in endothelial cells