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Neuronal Bmi-1 is critical for melatonin induced ubiquitination and proteasomal degradation of -synuclein in experimental Parkinsons disease models

Vitamin B12 is a nutrient commonly found in animal-based foods, so individuals who follow a vegetarian or vegan diet may be at a higher risk for Vitamin B12 deficiency

These findings align with previous studies suggesting that decreased mitochondrial function, specifically reprogramming glucose metabolism, and increased oxidative stress could underlie impaired responsiveness of hair cells to sound stimuli, ultimately leading to hearing loss [45,46,47]

B12 shots are taken to address deficiencies or to boost energy levels, as low levels of B12 can lead to fatigue, weakness, and mood changes