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Characterized by considerable clinical and morphological diversity and by their capacity to produce biologically active peptides and hormones, which frequently results in specific paraneoplastic syndromes, NENs remain a complex diagnostic and therapeutic challenge ( Within this context, immunotherapy, established over recent decades as one of the most dynamically evolving and promising fields in oncology, offers fundamentally novel mechanisms for combating tumors through the activation of the patients own immune system ( The principle of CAR T-cell therapy involves the ex vivo reprogramming of a patients autologous T-lymphocytes by equipping them with an artificially engineered receptor (CAR) designed to recognize a specific tumor-associated antigen

Sakaki et al., 1986)

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