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Mutation results in an approximately 3fold decrease in the I50 value of S-methyl-GSH Y108W - mutant enzyme shows 215% of the wild-type activity with 1,2-dichloro-4-nitrobenzene as substrate and 35% of the wild-type activity with 1,2-epoxy-3-(p-nitrophenoxy)propane, 16% of the wild-type GSH peroxidase activity towards cumene hydroperoxide and 36% of the wild-type steroid isomerase activity towards DELTA5-androstene-3,17-dione

And if we saw that that was in fact what we needed, that would be the timeframe wed use

J Biochem Biophys Methods

Studies have shown that hypoxic conditions within the TME reduce STAT3 activity in myeloid cells, a process linked to increased CD45 phosphatase activity