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Pirfenidone is an agonistic ligand for PPAR and improves NASH by activation of SIRT1/LKB1/pAMPK

Chin J Dermatol

Interestingly, we found that only VitB12 levels were significantly increased in the insomniac group and independently associated with the presence of insomnia after adjusting for confounding factors (which differed between the two groups and have been shown to impair sleep)