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Emphasizing preventive measures related to foot and eye care is crucial for patients with diabetes to minimize the risk of complications that could significantly impact their quality of life

Treatment is delivered in a series of injections and can be combined with other therapies such as PRP or shockwave therapy

Among these, mesenchymal stem cells (MSCs) have become the most promising therapeutic tools due to their self-renewal, multilineage differentiation potential, low immunogenicity, and immunomodulatory properties (Ogaili et al., 2025)

As the metabolic pathways related to homocysteine became delineated other important polymorphic variants were described, such as the thermolabile variant of the folate metabolizing enzyme, methylenetetrahydrofolate reductase (MTHFR) (5, 6)