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As shown in Figures 5D,E and Figure S4C in Supplementary Material, GSTP-S184D performed stronger inhibitory effect on LPS-induced HMGB1 release than GSTP (WT) in primary peritoneal macrophages, and RAW 264.7 and THP-1 cells, but GSTP-S184A showed a smaller influence

This dysregulation disrupts oxidative stress balance, impairs insulin signaling pathways, and alters both lipid and glucose metabolism[179]

The purified garlic fraction also inhibited renal Na + /K + -ATPase, likely by inhibiting the Na + -pump at the tubular Na + -reabsorption level in the kidneys (210)