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Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia 16 (3): 399403

The off period allows receptor density to normalize

Tirzepatide safety was established in over 7,700 participants, with primarily gastrointestinal side effects (nausea, diarrhea, vomiting) being the most common adverse events, typically mild to moderate and diminishing with continued use (Rosenstock et al., 2021

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