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Dysfunction or weakness in these muscles can further exacerbate imbalanced muscle activation patterns, indirectly increasing the load on the ACL

It may result in redness, irritation, and even collagen breakdown

Thus, we tested in genetic mouse models whether a moderate increase in VEGFA expression (~two to threefold, as it occurs in response to hypoxia or oxidative stress in aged tissues) leads to increased agerelated progressive pathologies in the lens and the retina, and whether genetic targeting of NLRP3 inflammasome components or of its regulators can inhibit the manifestation of these common but distinct aging eye pathologies

The condition is primarily caused by long-term exposure to irritants, with cigarette smoke being the most common culprit