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In the MET4-IO clinical trial, MET4 combined with ICIs demonstrated safety in advanced solid tumors and showed signs of efficacyincluding stable disease in 40% of patientsby reprogramming bile acid metabolism (elevating tauroursodeoxycholic acid) and enhancing CD8 + T cell infiltration (267)

the National Institutes of Health Institutional National Research Service Award (T32TR004396, B.D.C) and the National Institutes of Health K99GM138758 and R35GM155249 (S.K.)