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This mechanism has extensively been investigated in human depression but has not led to a faster onset of action in human depression (Hjorth, 2016

Diabetes mellitus is independently associated with more severe cognitive impairment in Parkinson disease

Stable 4T1 cell lines expressing the HaloTag protein from the pHaloTag-PS plasmid (where PS denotes the HSV-TK poly(A) signal) were generated as follows