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Tight and intricate regulatory processes maintain physiological H 2 S levels, while imbalances either in its production or breakdown have deleterious consequences, with high H 2 S levels eventually becoming toxic and/or pathogenic

Rohner, F

7.2 Mechanistic studies on low-dose and mixture effects Understanding the biological effects of low-dose chronic EED exposure and real-world chemical mixtures remains crucial for accurate risk assessment and regulatory decision-making

This charge-neutralized resonance form has traditionally been accepted as the most important source of the catalytic power of PLP, and is certainly important to the mechanisms of PLP enzymes that require a stabilized carbanionic intermediate as a component of the reaction mechanism: AAT requires a stabilized carbanionic intermediate to achieve the 1,3-proton transfer