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-KG is required for the activity of several enzymes, such as ten-eleven translocation methylcytosine dioxygenases, HIF prolyl 4-hydroxylases, and histone lysine demethylases

Mechanistically, siNrf2 transfection reverses these effects, indicating that Nrf2 mediates the proapoptotic effects of Res on fibroblast-like synoviocytes