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An alteration in the phosphorylation pattern, such as an increase in tyrosine phosphorylation, which results from pathological conditions, such as inflammation or elevated ROS, can alter the proteinprotein interactions of occludin with ZO-1, ZO-2, and ZO-3, and thereby alter the membrane integrity 75

437,438,439,440 Compared to neurotransmitters (approximately 5 ms), neuropeptides (approximately 20 min) display a substantially longer half-life and are stored in dense core vesicles, which are much larger in size and scope than synaptic vesicles