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It is noteworthy that iron metabolism, serving as a bridge linking the microbiota to host pathological processes, exhibits bidirectional regulatory properties: the hosts iron reserve status can significantly influence gut microbiota composition, while specific bacterial strains can reshape host iron distribution by modulating the expression of iron absorption-related proteins

FIGURE 2 Investigating ferroptosis not only expands our knowledge of the intricate mechanisms underlying migraines, but it also creates new opportunities for locating possible targets for treatment

Conversely, they induce the downstream signaling pathways involving protein kinases of the MAPK and phosphoinositide 3-kinase (PI3K) cascades [12]

Reduced astrocytic presence impaired glutamate clearance and K + buffering thus affecting synaptic plasticity