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The interaction between HOX and MEIS TFs is well-established in a variety of organisms and tissues (Bobola and Sagerstrm, 2024), but its significance in cardiac development remains underexplored

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This research found that BNC1 deficiency in oocytes affects the NF2-YAP-TFRC/ASCL4 signaling axis, upregulates the expression of TFRC and ACSL4, induces oocyte ferroptosis, which ultimately leads to oocyte death and follicular atresia

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