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Fernndez-Villa, D., Aguilar, M

1 Previous studies have shown the crosstalk between Ras/ERK and PI3K/AKT pathway and thus inhibition of one pathway may induce activation of the other one

Reductions in GABA levels found in patients with ALS in motor cortex compared to healthy controls (Foerster et al., 2012, 2013) may contribute to cortical hyperexcitability