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Supporting this, MS analyses under denaturing conditions showed that haem-mediated PGRMC1 dimer is completely dissociated into monomer, indicating that dimerization of this kind is not mediated by any covalent bond such as disulfide bond (Supplementary Fig

54 Ferroptosis caused by excessive HMOX1 activity is called non-canonical ferroptosis

They can help break down circulating immune complexes, degrade excess fibrin (which is highly relevant for the microclots seen in Long COVID), and modulate systemic cytokine levels