foxo4 dri senolytic peptide human trial 2024 Frontiers FOXO4-DRI induces keloid senescent fibroblast

FOXO4 DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53 serine 15 phosphorylation Communications Biology The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4 DRI Nature Communications CHK2 USP37 axis stabilizes FOXO4 to sustain senescence and evade apoptosis PNAS Molecular modelling of the FOXO4 TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells ScienceDirect

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