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B Model structure of the two novel ferrostatin derivates SRS16-79 (inactive compound) and SRS16-86 (active compound)

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Tumor microenvironment affects tumor cell metabolism, immunity and therapeutic effect, and plays a core role in tumor occurrence and development ( 1.1 The concept of ferroptosis Ferroptosis is a unique form of iron-dependent cell death, which is caused by excessive accumulation of lipid peroxide on the cell membrane ( Studies have shown that ferroptosis is closely related to iron, lipid and amino acid metabolism