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10.7150/thno.47627 29 PerlmanS

doi: 10.1126/science.aal3535 164 MassaguJSheppardD

Mechanisms leading to the neurodegenerative process in glaucoma include ischemia/hypoxia, mitochondrial dysfunction, oxidative stress, and neuroinflammation, among others

The excessive generation of reactive oxygen species (ROS) or insufficient antioxidant capacity within an organism triggers a cascade of lipid peroxidation reactions that compromise cell membranes, ultimately leading to cell death and accelerating aging