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Metz and Maurer, 2007)

(2001) pre-treated primary midbrain cultures with different doses of buthionine sulfoximine (BSO) a specific inhibitor of GCL, the rate-limiting enzyme in GSH synthesis

In contrast, GSSG is less susceptible to decomposition in aqueous solution and is suitable for use in liquid form, although the skin-whitening effect of topical GSSG is unknown