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Inhibition of polyamine uptake potentiates the anti-proliferative effect of polyamine synthesis inhibition and preserves the contractile phenotype of vascular smooth muscle cells

CBD-loaded extracellular vesicles alone or in combination with doxorubicin reduced inflammation and metastasis and promoted apoptosis in the MDA-MB-231 cell line through cell cycle arrest in G1 phase and downregulation of IL-17, NF-B, Twist, phosphorylated transducer and activator of transcription-3 (pSTAT3), STAT3 proteins in vitro

Mol Biol Cell 2004;15:50015011

the capacity to invade other organs and tissues, a process known as metastasis