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6-Bromo-6-deoxy-L-ascorbic acid: An ascorbate analog specific for Na +-dependent vitamin C transporter but not glucose transporter pathways

In particular, vitamin C supplementation has been shown to enhance endothelial function under acute inflammatory conditions and improve the left ventricular ejection fraction in post-myocardial infarction patientsespecially those with reduced baseline ejection fraction, as demonstrated in the meta-analysis by Hemil et al

Additionally, the FRAP assay does not measure thiol-based antioxidants like glutathione and primarily evaluates reducing capacity based on the ferric ion, which is not directly linked to the mechanistic or physiological relevance of antioxidant activity

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