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Cardiac hypertrophy, a common feature to many cardiovascular diseases [207], may also be potentially treated with NR, as OG administration with this precursor in a murine model of myocardial TAC-induced hypertrophy triggered SIRT3 activation through the regulatory SIRT3/MnSOD axis

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Hardie LJ, Briggs JA, Davidson LA, Allan JM, King RF, Williams GI, Wild CP

Since the primary deficiency disease associated with vitamin K is bleeding due to impaired blood clotting, it is commonly believed that high intake of vitamin K may increase the risk of thrombosis