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There is evidence for pituitary dysfunction after mild to severe TBI in children (Casano-Sancho et al., 2013

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ii) Primary culture of satellite cells with 5 ng/ml HGF, which received only the LASSS pre-treatment (at 1:8000, without peroxynitrite treatment), exhibited a cell-proliferation activity (evaluated by mRNA expression levels of MyoD and its counter-regulatory factor myogenin at 48-h and 72-h time-points) comparable to that of the positive control culture treated with 5 ng/ml control HGF without LASSS (just with the solvent

The authors stratified their results based on the severity of hepatic encephalopathy at the time of inclusion and demonstrated that NAC-treated patients with mild hepatic encephalopathy (grade I and II) had better survival compared to controls