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82074378), the innovation team and talents cultivation program of National Administration of Traditional Chinese Medicine (ZYYCXTD-C-202207), the Project of Science & Technology Department of Sichuan Province (No

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These mutations disrupt iron homeostasis by phosphorylating Rab8a, leading to the sequestration of Tf within lysosomes and potentially promoting iron accumulation and ferroptosis

Acknowledgements The authors wish to acknowledge grant support from the German Research Foundation (DFG), Clinical Research Unit KFO 181, projects 1 (STE 892/9-2) and 6 (SCHA 1531/1-1)