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First, metabolic reprogramming serves as a central driver

The clinical implication of our findings is to use TdGSH to prevent progressive loss of -cell mass in diabetic patients, who have more glycaemic variabilities because of the vicious metabolic memory obtained from the disease, and to block the development of diabetic complications

Remarkably, these effects were observed at a glutamate concentration three times lower than that present in human milk, highlighting the potency of free glutamate in human milk to exert physiological effects

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