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Vitamin B12 is essential for energy production, nervous system health, and red blood cell formation

Clinical Benefits: Regulates calcium and phosphate metabolism for bone and muscle health Supports immune system modulation and reduces susceptibility to infection Associated with improved mood and reduced risk of seasonal affective symptoms May help reduce systemic inflammation Supports neuromuscular function Effective for patients with malabsorption conditions or persistent oral supplementation failure A blood test can be arranged to confirm deficiency prior to treatment, though this is not always required

However, several medicines and substances can reduce the absorption or levels of vitamin B12 , including metformin, proton pump inhibitors, colchicine, chloramphenicol, aminosalicylic acid, neomycin, and heavy alcohol use

5-Amino-1MQ targets the substrate binding site of NNMT the nicotinamide binding pocket competitively inhibiting nicotinamide methylation with an IC50 of 1.2 M under reference assay conditions