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J Biol Chem 277:3916339168 MacDonald MJ, Efendic S, Ostenson CG (1996) Normalization by insulin treatment of low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of the GK rat

thus it seems highly likely that these processes occur in konzo, a motor neuron disease triggered in part by the consumption of toxic compounds that are well established to increase oxidative stress 43

Similarly, one study showed that Tmed4(-/-) mice had endogenous regulatory T (Treg) cells that shifted toward a more inflammatory phenotype with enhanced anti-tumor activity in a colorectal cancer model (84)

Supplementation of glucose-free media with L-cysteine instead of L-cystine led to increased intracellular levels of both L-cysteine and L-cystine, which may reflect either intracellular or extracellular oxidation of L-cysteine