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J Med Chem (2021) 64(9):525275

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The p53 protein, a key human tumor suppressor, regulates the expression of oncogenes and downstream signaling pathways, contributing to biological effects (7275): Beyond its role in cancer, p53 is highly expressed in the brain, where it influences dendritic growth, oxidative stress response, apoptosis and autophagy, making p53 dysfunction and associated pathways noteworthy in the pathogenesis of AD (7678)

Erythrocyte NAD(H) levels started to saturate already with 500-750 mg of niacin and increasing the dose up to 1000 mg had only a slight additional effect on steady-state NAD + in blood cells