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In the presence of oxidative stress or specific electrophilic stimuli , critical cysteine residues on KEAP1 undergo modifications that disrupt KEAP1-mediated repression, resulting in the stabilization and release of Nrf2

Because of this, depletion of GSH is considered the primary step of ferroptosis [47]

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Effect of alcohol abuse and glutathione administration on the circulating levels of glutathione and on antipyrine metabolism in patients with alcoholic liver cirrhosis