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Acidosis-induced activation of GPR4 promotes the endoplasmic reticulum (ER) stress response and apoptosis of endothelial cells (177, 179, 180)

A significant decrease in daily calories intake was observed in the low-carbohydrate group (from 2205 624 kcal to 1667 404 kcal, p = 0.004), whereas no significant change occurred in the high-carbohydrate group

JAK/STAT was a common signal transduction pathway activated by many cytokines

Epigenetic therapy for cardiovascular disease DNA methylation DNA methyltransferase inhibitors or related drugs play a role in the treatment of cardiovascular diseases such as coronary heart disease and heart failure by regulating target genes methylation status and expression level (Figs