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Following NaHS treatment, T6-P may be preferentially used for energy contingency (glycolysis) rather than trehalose synthesis leading to a decrease in its content or direct involvement of trehalose in osmoregulation [91] (Fig

doi:10.1016/j.freeradbiomed.2019.11.021 Heart Health and Cardiovascular Research Although not a primary research area, MOTS-cs effects on insulin sensitivity, lipid metabolism, and inflammation may indirectly benefit cardiovascular health

More reports mention the Three-Hit Hypothesis, involving dysregulated lipid metabolism, mitochondrial dysfunction with decreased fat degradation, and oxidative stress that happens in cycles in the progression of MASLD cases [231, 232]

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