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Let the water gently dissolve the powder

Many mammals evolved smaller body sizes as an adaptation to ecological stresses, such as food scarcity, enabling faster reproduction that promoted species survival and evolution

As to a connection with ER stress, many xenobiotics have been shown to influence the UPR signalling route, with either pro-survival or pro-death features - unsurprising given that resident CYP straddle ER membranes (84)